The IDRome folder contains the database of conformational ensembles for 28,058 sequences of the human intrinsically disordered proteome. The directories are organized by splitting the UniProt IDs into two- or four-character units in a hierarchical fashion. For example, the conformational ensembles and precalculated conformational properties for the 97-aa-long N-terminal IDR of NP1L3 (UniProt ID: Q99457) are contained in the folder Q9/94/57/1_97. Python code, Jupyter Notebooks, and data for reproducing all the results presented in the manuscript "Conformational ensembles of the human intrinsically disordered proteome" are available at https://github.com/KULL-Centre/_2023_Tesei_IDRome and at https://doi.org/10.5281/zenodo.10251736. The Excel Sheet Supplementary_Table_3.xlsx lists amino acid sequences, sequence feature, and conformational properties of all the 28,058 IDRs. The Previous_Versions folder contains previous versions of this work.